Senior Scientist I (Pharmacology)
Senior Scientist I (Pharmacology)
Every Exelixis employee is united in an ambitious cause: to launch innovative medicines that give patients and their families hope for the future. In this pursuit, we know our employees are our most valuable asset. After operating in the challenging biotech sector for 25 years, we have a proven track record of resiliency in the face of adversity. The success of our lead product has provided a solid commercial foundation allowing us to reinvigorate our research efforts, and grow our team in areas such as Drug Discovery, Clinical Development and Commercial.
As we expand our global partnerships and further reinvest in R&D to help us discover the next breakthrough for difficult-to-treat cancers, we’re seeking to add talented, dedicated employees to power our mission.
Cancer is our cause. Make it yours, too.
Exelixis is seeking a highly self-motivated, interactive, and productive hands-on PhD scientist to join the Pharmacology team working towards discovery of anti-cancer agents for the treatment of targeted indications. The successful candidate will be a highly creative scientist with a strong desire to succeed at the highest level. This individual will have strong knowledge and experience in setting up tumor models in animals and incorporate the latest technologies into Pharmacology functions. Will assume shared responsibility for the management and development of the Pharmacology laboratory as part of the PD/Efficacy team.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
• Design, execute and interpret in vivo pharmacology experiments to test the selected compounds in rodent models of cancer.
• Establish efficacy/PK/PD relationship; characterize toxicity profile for the preclinical therapeutic candidates.
• Utilize literature and internal data sets to design and test hypotheses for drug targets.
• Represent Pharmacology function on discovery teams and lead sub-teams.
• Provide scientific support for the project teams and Discovery/ Pharmacology staffs.
• Prepare technical reports for research findings and IND filings.
• Contribute to scientific writing projects associated with ongoing Discovery efforts.
• Collaborate with the IACUC committee to ensure compliance with internal policies and animal welfare regulations.
• PhD in Pharmacology, Cancer Biology, Molecular Cellular Biology, or a closely related field and zero to three years of industrial experience after post-doctoral training.
• A broad understanding of in vitro and in vivo Pharmacology, PK, PD and I/O concepts within the cancer biology field is essential.
• Extensive experience using in vivo oncology models for drug discovery with proven track record in establishing, validating and implementing animal models for testing cancer therapies including xenograft, syngeneic, genetically engineered mouse, orthotopic, PDX and humanized models to study biologic mechanisms.
• Proven track record of writing regulatory and IND filing documents in the pre-clinical Pharmacology section.
• Proven track record of good experimental design, in-depth data analysis and interpretation based on strong scientific rationale.
• Expertise in cell culture with aseptic technique is essential.
• Experience in utilizing imaging modalities in tumor research is desired.
• Experience with immunophenotyping of cells from in vivo studies is preferred.
• Strong scientific expertise with good track records of publications.
• Managerial experience related in in-vivo pharmacology personnel is required.
• In vivo skills include but not limited to animal handing, dosing with different routes (po, iv, sc, ip etc.), blood collection, tissue collection/ perfusion, necropsy, tumor measurement, clinical observation, rodent survival surgeries and in vivo imaging modalities.
• Has flexibility to accommodate to fast-paced work environment and deadlines.
• Works independently; self-motivated and innovative.
• Ability to work in a team-based environment and coach junior scientists.
• Excellent oral and written communication and presentation skills in English.
• Detail-oriented and able to problem solve and offer potential solutions.
• Experience with immunophenotyping of cells from in vivo studies is a plus.
• Solid background in laboratory bench skills such as Western blotting, ELISAs, qPCR, Flow cytometry, and/or histology is required.
• Advanced knowledge of Excel, Word, PowerPoint, PDF, Graphpad Prism is required. Capability of using Studylog, ELN notebook, and FlowJo is preferred.
• Performs a variety of complicated tasks with a wide degree of creativity and latitude
• Works on complex problems where analysis of situations or data requires an in-depth evaluation of various factors
• Exercises independent judgment in developing methods, techniques, and evaluation criteria for obtaining results
• Uses professional concepts to contribute to development of company concepts and principles and to achieve objectives in creative and effective ways.