Our Partners
Our Partners
High Impact Relationships Accelerate Results
In medicine, we know that successful treatment regimens require an understanding of how to develop and deploy the right drug or drug combination at the right time. That’s why Exelixis has a long history of leveraging productive partnerships and collaborations to move our molecules and our business forward. Our model for value creation is built upon a disciplined use of resources and a vast oncology clinical development and commercialization network. Our strategy is enhanced by our history of prolific drug discovery, aptitude for recognizing the missed potential of validated targets and ability to focus on oncology assets that are asymmetrically valued or misunderstood. With a focused, nimble team, we fully commit to our programs and partnerships.
Today, we’re oriented around three types of collaborative relationships:
Maximizing the opportunities for our flagship product, cabozantinib: We have an extensive, long-term pipeline strategy for cabozantinib and are focused on expanding the therapeutic potential of the molecule through broad clinical development. See our collaborations with Ipsen, Takeda, Bristol Myers Squibb, and Genentech.
Working together to identify the next generation of Exelixis medicines: In addition to conducting its own internal drug discovery activities, Exelixis is actively seeking in-licensing or acquisition opportunities to bring promising technologies, product candidates or other assets into its pipeline. See our collaborations with StemSynergy, Invenra, Iconic, Aurigene, Catalent, and NBE-Therapeutics.
Exelixis discoveries moving forward in the hands of partners: Our history of productive drug discovery includes partnering multiple compounds and programs with leading pharmaceutical and biopharmaceutical companies. See our collaborations with Daiichi Sankyo, and Genentech.
Aurigene
In July 2019, Exelixis entered into an exclusive collaboration, option and license agreement with Aurigene Discovery Technologies Limited (Aurigene) to discover and develop novel small molecule therapies for cancer. The agreement gives Exelixis the opportunity to in-license as many as six programs from Aurigene, which has developed a focused approach to drug discovery that targets differentiated first-in-class and best-in-class opportunities with unique mechanisms of action. Exelixis will contribute research funding to Aurigene to facilitate discovery and preclinical development work on all six programs. As the programs mature, Exelixis will have the opportunity to exercise an exclusive option for each program up until the time of Investigational New Drug acceptance. If Exelixis decides to exercise an option, it will assume responsibility for that program’s future clinical development and commercialization including global manufacturing. Under the terms of the agreement, Aurigene will be eligible for clinical development, regulatory, and sales milestones, as well as royalties on sales, and retains limited development and commercial rights for India and Russia.
Bristol Myers Squibb Company
In October 2010, Exelixis entered into a worldwide collaboration with BMS to discover, optimize and characterize ROR modulators that could be subsequently developed and commercialized by BMS. BMS continues to advance the program and in 2017, filed a Clinical Trial Authorization in Europe for the first in-human study of a RORt inverse agonist. Exelixis is eligible for development, regulatory and commercial milestone payments, as well as royalties on commercial net sales, depending on the advancement of the product candidate and eventual product.
In February 2017, Exelixis entered into a clinical collaboration agreement with BMS for the purpose of conducting clinical studies combining CABOMETYX® (cabozantinib) tablets with BMS’ Opdivo® (nivolumab) and Yervoy® (ipilimumab). As part of this collaboration, Exelixis and BMS initiated CheckMate 9ER, a phase 3 trial evaluating Opdivo in combination with CABOMETYX versus sunitinib in patients with previously untreated, advanced or metastatic renal cell carcinoma (RCC), and CheckMate 040, a phase 1/2 trial evaluating the same combination and also CABOMETYX with both Opdivo and Yervoy versus sorafenib in patients with both previously treated and previously untreated advanced hepatocellular carcinoma (HCC).
Catalent
In September 2020, Exelixis entered into a collaboration and license agreement with Catalent under which the latter’s Redwood Bioscience subsidiary will develop multiple antibody-drug conjugates (ADCs) for Exelixis using Catalent’s proprietary SMARTag® site-specific bioconjugation technology. The agreement gives Exelixis an exclusive option to nominate up to four targets using the SMARTag® ADC platform over a three-year period. The companies will seek to advance the ADCs into preclinical development, and, prior to filing an Investigational New Drug application, Exelixis may exercise its exclusive option to a worldwide license of the related ADC program and continue clinical development and commercialization. Exelixis will provide R&D funding, and Catalent will be eligible for development and commercialization milestones and royalties on net sales of any product commercialized as part of the collaboration.
Daiichi Sankyo
In March 2006, Exelixis entered into a collaboration agreement with Daiichi Sankyo for the discovery, development and commercialization of novel therapies targeting the mineralocorticoid receptor. One of the compounds developed during this research collaboration is esaxerenone (CS-3150), an oral, non-steroidal, selective blocker of the mineralocorticoid receptor (MR), which Daiichi Sankyo subsequently took forward. In January 2019, the Japanese Ministry of Health, Labour and Welfare approved esaxerenone as a treatment for patients with hypertension in Japan, where the medicine is marketed as MINNEBRO®. Daiichi Sankyo is also conducting additional clinical trials of esaxerenone in Japan. Exelixis is eligible to receive commercialization milestones, as well as low double-digit royalties on sales of esaxerenone.
Roche / Genentech
In December 2006, Exelixis out-licensed cobimetinib, which it discovered internally, to Genentech via a worldwide collaboration agreement. Approved in 2015 for the treatment of a form of advanced melanoma and marketed as COTELLIC®, Exelixis and Genentech share in commercialization costs and ultimately profits/losses from COTELLIC in the United States, where Exelixis also has co-promotion rights. Outside the U.S., Exelixis is eligible to receive and is receiving royalties on COTELLIC sales.
In addition to its cobimetinib partnership, Exelixis is collaborating with Genentech’s parent company, Roche, on clinical development activities evaluating cabozantinib in combination with atezolizumab, Roche’s anti-PD-L1 immune checkpoint inhibitor. This work began with COSMIC-021, a phase 1b trial in multiple locally advanced or metastatic solid tumors, which has informed late-stage clinical development plans including the COSMIC-312 trial in advanced hepatocellular carcinoma. Based on the COSMIC-021 experience, in December 2019, Exelixis and Roche entered into another clinical collaboration for three additional phase 3 pivotal trials of the cabozantinib/atezolizumab combination in forms of non-small cell lung cancer (CONTACT-01), castration-resistant prostate cancer (CONTACT-02), and renal cell carcinoma (CONTACT-03).
Iconic Therapeutics
In May 2019, Exelixis entered into an exclusive option and licensing agreement with Iconic Therapeutics, Inc. (ICONIC) to advance an innovative next-generation antibody-drug conjugate (ADC) program for cancer. The agreement grants Exelixis an exclusive option to license ICON-2, Iconic’s lead oncology ADC, a potential best-in-class program targeting Tissue Factor in solid tumors. If Exelixis elects to exercise its option at the time of a potential investigational new drug filing, it will assume all further clinical development and commercialization activities, while Iconic will become eligible for future milestone payments and royalties on potential sales.
Invenra
In May 2018, Exelixis entered into a collaboration with Invenra to discover and develop novel biologics to treat cancer. The agreement grants Exelixis an exclusive, worldwide license to one preclinical asset, currently in lead selection against an undisclosed target, and forms a collaborative partnership enabling the two companies to pursue up to six additional discrete projects, in total directed to three discovery programs, through the use of Invenra’s B-Body™ technology platform. Exelixis will lead investigational new drug (IND)-enabling studies, manufacturing, clinical development in single-agent and combination therapy regimens, as well as future regulatory and commercialization activities. Invenra will be responsible for antibody lead discovery and generation and will be eligible to receive pre-clinical, clinical development, regulatory and commercialization milestones for any product containing a lead preclinical asset in the first indication as well as royalties on net sales.
Ipsen
In February 2016, Exelixis entered into an exclusive licensing agreement with Ipsen for the commercialization and further development of cabozantinib. Ipsen is now Exelixis’ global partner for cabozantinib in all geographies outside of the United States and Japan. Exelixis has received to date significant development and regulatory milestone payments from this collaboration, and is eligible to receive additional capital from commercial milestones and royalties on net sales of cabozantinib in Ipsen’s territories. Ipsen can opt in to funding additional cabozantinib clinical trials, thereby gaining access to the results to support potential future regulatory submissions in its territories.
Merck
In December 2011 Exelixis granted an exclusive worldwide license to its PI3k-delta program, including XL499 and other related compounds. Merck retains the sole responsibility to research, develop and commercialize compounds from this program, one of which is currently the subject of a phase 1 trial. Exelixis is eligible for payments associated with the successful achievement of development and regulatory milestones for multiple indications of compounds within the PI3k-δ program.
NBE-Therapeutics
In September 2020, Exelixis entered into a collaboration and license option agreement with NBE-Therapeutics to discover and develop multiple antibody-drug conjugates (ADCs) for oncology applications by leveraging NBE’s unique expertise and proprietary platforms in ADC discovery, including SMACTechnology™ (a site-specific conjugation technology) and novel payloads. The agreement provides Exelixis an exclusive option to nominate four targets on NBE’s ADC platform over a two-year period. The companies will seek to advance multiple ADCs into preclinical development, with Exelixis contributing R&D support. For each individual target program, prior to filing an Investigational New Drug application, Exelixis will be able to exercise its option to an exclusive worldwide license, and afterwards continue clinical development and commercialization activities for that target program. Upon exercise of any option, NBE will be eligible for development and commercialization milestones, as well as royalties on net sales of any potential products resulting from that target program.
Sanofi
In May 2009, Exelixis entered into an out-license agreement with Sanofi for two internally discovered compounds, SAR24508 (XL765) and SAR24509 (XL765), both of which are inhibitors of phosphoinositide-3-kinase (PI3K) and are available to be taken orally. Both compounds have been evaluated by Sanofi as single agents and in combination regimens within a variety of cancer indications.
StemSynergy Therapeutics
In January 2018, Exelixis entered into an exclusive licensing agreement with StemSynergy for the discovery and development of novel oncology compounds targeting Casein Kinase 1 alpha (CK1α), a component of the Wnt signaling pathway implicated in key oncogenic processes. Exelixis will contribute research and development funding and be solely responsible for commercialization of any products resulting from the collaboration. StemSynergy will be eligible to receive development, regulatory and commercial milestones, as well as royalties on worldwide sales.